Albumin Globulin Ratio Calculator | A/G Ratio (2024)

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What is A G ratio?What is the albumin globulin ratio used for? 🤔What is a normal AG ratio?What does a high AG ratio mean?How to calculate albumin globulin ratio?FAQs

Welcome to the albumin globulin ratio calculator! We'll show you everything you need to know about the AG ratio meaning and the AG ratio blood test. 💉

We won't stop at basic definitions — keep on reading to:

  • Learn more about the different proteins in our body;
  • Find out how to calculate albumin globulin ratio; and
  • Discover the normal albumin globulin ratio ranges.

❗ The albumin globulin ratio calculator cannot be used as a substitute for clinical knowledge and/or consultation with a medical specialist. Always consult your doctor.

What is A G ratio?

The AG ratio is the abbreviation for the albumin globulin ratio, sometimes called the alb glob ratio. It's obtained with a quick test performed on a blood sample. This proportion tells us about the relation of two important proteins in our body:

  • Albumins are the most common proteins in human blood. They bind to different substances and regulate the oncotic and osmotic pressure. Their normal range is 3.5–5.2 g/dL.
  • Globulins are produced by the liver and the immunological system (antibodies!). They have higher protein molecular weight than albumins. Their normal range equals 2.6–3.5 g/dL.

What is the albumin globulin ratio used for? 🤔

The physicians use the A/G ratio to diagnose different diseases associated with abnormally low or high levels of proteins and/or check for eventual malnutrition. The list of possible disorders is long and may include dehydration, HIV/AIDS, kindey failure or liver failure.

Want to know more about the liver damage? Why don't you start with the AST ALT ratio calculator. 📍

What is a normal AG ratio?

The albumin globulin ratio's normal range varies depending on the quoted source — it's been reported as either:

  • 1.2–2.2;
  • 1.5–2.5;
  • 0.5–1.2; or
  • 1.1–2.5.

Usually, a A G ratio of 1.0 or less is considered significant. The same goes for values over 2.5. Consult your local laboratory on their specific ranges.

What does a high AG ratio mean?

The meaning of a A high A/G ratio depends on the state of the patient, their signs, symptoms and reported complaints.

Let's say that your AG ratio is 2.5, meaning it's way too high than it should be. Let's look at all the disorders that may be responsible for this result:

  • Dehydration (high levels of albumin, due to lack of water);
  • Leukemia (impaired globulin production);
  • Immunodeficiency, e.g., HIV or genetic disorders (impaired globulin production); or
  • Drug interactions.

How to calculate albumin globulin ratio?

We can help you with this simple task! The formula you need looks as follows:

A/G Ratio = Albumin / (Total protein − Albumin)

Where both Albumin and Total protein are given in g/dL.

Happy with our AG ratio calculator? We have plenty of amazing ratio tools to discover — like:

  • The protein creatinine ratio calculator that helps to determine the proteinuria; and
  • The article that will acknowledge you with CKD stages and albuminuria - the albumin creatinine ratio calculator.
FAQs

How do I calculate the AG ratio if my Albumin is 4 g/dL?

To calculate the A/G ratio with an albumin level of 4 g/dL, assuming a total protein level is 7 g/dL, follow these steps:

  1. Subtract the albumin level (4 g/dL) from the total protein (7 g/dL).
  2. Divide the albumin level (4 g/dL) by the difference obtained in step 1 (3 g/dL).
  3. That's all! You have now determined that the A/G ratio is 1.3333.

What does it mean to have the AG ratio of 1.0?

Usually, a ratio of 1 is considered to be too low. A low A/G ratio might be indicative of:

  • Inflammation (overproduction of globulin);
  • Liver disease (impaired production of albumin);
  • Kindey disease, e.g., nephrotic syndrome (loss of albumin in urine);
  • Autoimmune disease (excessive production of immunoglobulin — antibodies); or
  • Myeloma (excessive production of immunoglobulin — antibodies).

What does it mean to have the AG ratio of 2.4?

The A/G ratio of 2.4 is considered to be high. Elevated AG ratios can be associated with various medical conditions, including dehydration, leukemia, immunodeficiency, and specific drug interactions. If you have received a blood test result indicating a high A/G ratio, it's essential to consult with a healthcare provider for a comprehensive evaluation.

How is the AG ratio obtained?

The A/G ratio (short for the Albumin-Globulin ratio) is obtained through a blood test. The indicator provides essential information about the balance of two critical proteins in your body – albumin and globulin. To calculate your A/G ratio and learn more, visit the Omni albumin globulin ratio calculator!

ACFT Calculator
Albumin Globulin Ratio Calculator | A/G Ratio (2024)

FAQs

Is a 3.1 A/G ratio bad? ›

A test result with a ratio less than 1 or more than 2.5 is considered bad.

How is the A/G ratio calculated? ›

To determine the A/G Ratio, the concentration of albumin and globulins in the blood is measured; subsequently, the A/G Ratio is calculated by dividing the albumin concentration by the globulin concentration. Fasting is typically required for this test.

Is 2.6 a high Ag ratio? ›

A normal A/G ratio is between 1.1 and 2.5, although this can vary by lab. A low A/G ratio may be due to kidney disease, liver disease, chronic infections, type 2 diabetes, malnutrition, certain autoimmune diseases, and cancers.

What should I do if my ag ratio is high? ›

There is no single treatment for a high or low A/G result, as this will vary depending on the underlying health condition. Treatment will also depend on any other exams or tests your doctor performs regarding your symptoms.

Should I worry if my A G ratio is low? ›

Low A/G ratio: This might be the sign an autoimmune disorder, where your body's immune system attacks healthy cells. It can also point to kidney disease or cirrhosis, which is inflammation and scarring of the liver. In some cases, a low A/G ratio can be a sign of a tumor in your bone marrow.

What is an alarming globulin level? ›

Results more than 3.5 g/dL for globulin and more than 2.5 for an albumin/globulin ratio are considered high. But being on bed rest for too long, dehydration, and problems during the blood draw can also cause a high reading. Your healthcare provider will likely order additional tests.

What is a normal A G ratio for a woman? ›

The A/G ratio is a measure of the amount of albumin proteins in blood compared to globulins. Typically, your body has slightly more albumin than globulins. A normal A/G ratio is slightly more than 1.

What is the optimal G ratio? ›

A fibre with a g ratio of 0.6 will have the maximum conduction velocity for its length. Note that the theory applies to a generic (peripheral and central) myelinated axon. The optimal g-ratio was obtained from purely theoretical considerations, namely by maximising conduction velocity in the equation.

Why would albumin be low? ›

Albumin is protein in your blood plasma. Low albumin levels might be the result of kidney disease, liver disease, inflammation or infections. High albumin levels are usually the result of dehydration or severe diarrhea.

Is 3.7 high for globulin? ›

Normal value ranges are: Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L)

What is the Ag ratio in a liver function test? ›

The test also compares the amount of albumin in your blood to the amount of globulin. The comparison is called the albumin/globulin (A/G) ratio. If your total protein levels or A/G ratio results are not normal, it can be a sign of a serious health problem.

Does low globulin make you tired? ›

Corticosteroid-binding globulin deficiency is a condition with subtle signs and symptoms, the most frequent being extreme tiredness (fatigue), especially after physical exertion. Many people with this condition have unusually low blood pressure (hypotension).

Can AG ratio be lowered? ›

A low A/G ratio has been associated with many illnesses, which may be related to inflammation or certain cancer such as myeloma. The A/G ratio can be decreased with short-term problems that cause inflammation, such as tissue trauma or infection, chronic inflammatory conditions, and nutritional problems.

How do you calculate a G ratio? ›

Total serum protein = Albumin + Globulin Globulin =Total serum protein – Albumin = 6.82- 3.93 = 2.89 gm/dL So, A/G ratio = Albumin / Globulin = 3.93 / 2.89 A/G ratio = 1.35 gm/dL (Ans.)

What are symptoms of high albumin levels? ›

If symptoms are present, you may notice one or more of the following:
  • Foamy urine.
  • Puffiness around the eyes (especially in the morning)
  • Frequent urination (peeing more often than usual)
  • Swelling of your feet, ankles, belly area, or face.

Is 3.8 globulin normal? ›

Normal Results

Normal value ranges are: Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L) IgM component: 120 to 400 milligrams per deciliter (mg/dL) or 1.2 to 4 g/L. IgG component: 800 to 1600 mg/dL or 8 to 16 g/L.

Should I be worried about slightly high protein in blood? ›

High blood protein is an increase in the concentration of protein in the bloodstream. The medical term for high blood protein is hyperproteinemia. High blood protein is not a specific disease or condition, but it might indicate you have a disease. High blood protein rarely causes symptoms on its own.

Can low protein in blood be serious? ›

If your total protein level is low, you may have a liver or kidney problem, or it may be that protein isn't being digested or absorbed properly. A high total protein level could indicate dehydration or a certain type of cancer, such as multiple myeloma, that causes protein to accumulate abnormally.

What does a globulin level of 1.8 mean? ›

Optimal Result: 1.5 - 4.5 g/dL, or 15.00 - 45.00 g/L. What is globulin? Globulin is a protein and is made in the liver. High levels may indicate autoimmune disease, infections or cancer. A low globulin reading may be a sign of liver or kidney disease.

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